TOXOPLASMOSIS CONTROL IN OVINE BY A GENOMIC AND ECOSYSTEM APPROACH
Toxoplasma gondii is the main causative agent of abortion in sheep. The aim of this project is to determine the existing genetic diversity amongst strains of Toxoplasma gondii affecting the reproductive potential of sheep in Uruguay, and to develop tools to help with early diagnosis and prevention. Funding of this project is by the National Agency for Research and Innovation (ANII)
THE MOLECULAR BASIS OF SEXUAL DIFFERENTIATION
Toxoplasma gondii assembles two flagella in the sexually differentiated stage called the microgamete. We aim to understand how these are organized by basal bodies, and what the BB assembly pathway is. This project is funded by the Pasteur Network
MITOCHONDRIAL GENOME DIVERSITY
We aim to understand the sources and phenotypic implications of mitochondrial genome diversity in T. gondii. This project is led by Dr. Luisa Berna, and funded by CSIC
THE API CENTROSOME: ITS ROLE IN CELL DIVISION AND DIFFERENTIATION
The ability of apicomplexan parasites to proliferate within their host cells is paramount to their pathogenicity. In this project, we aim to identify novel components of the centrosome, an organelle with a central in cell division. Our laboratory coordinates an international team involving the laboratories of Dr. Mathieu Gissot (IP Lille) and Dr. Philippe Bastin (IP Paris) focused on protozoan MTOCs. Funding of this project is by the Pasteur Network
THE MOLECULAR BASIS OF TRANSPLACENTAL TRANSMISSION
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We aim to understand the molecular basis of the interaction between the maternal-fetal interface and T. gondii, with a focus on how the placenta responds to infection and the parasite factors enabling transmission. This project is funded by the Pasteur Network
RESEARCH PROJECTS
